HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids.

feeding behavior and starvation. In D. melanogaster the regulation of Twz, TfAp2, Hmgcr and G9a were significantly affected by different periods of starvation.

2015-08-01 The ELISA kits listed below target HMGCR, the symbol for the human gene, 3-hydroxy-3-methylglutaryl-CoA reductase, and a member of the HMG-CoA reductase family. The protein encoded by HMGCR has a predicted amino acid length of 888 and a mass of 97.5 kDa. There are currently 3 reported isoforms, as well as sites of glycosylation. HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes.

Anti-HMGCR Myopathy. The feeding-induced stabilization of HMGCR is abolished in mice with liver-specific Usp20 deletion and in USP20(S132A/S134A) knock-in mice. Genetic deletion or pharmacological inhibition of USP20 markedly decreases diet-induced body weight gain, reduces lipid levels in the serum and liver, improves insulin sensitivity and increases energy expenditure. HMGCR : Necrotizing autoimmune myopathy (NAM) is a serious but rare muscle disease strongly associated with autoantibodies to either signal recognition protein (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).(1) NAM typically manifests with subacute proximal limb muscle weakness and persistently elevated serum creatine kinase (CK) concentrations, but slower onsets can occur and … 2014-11-24 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase Gene ID: 3156, updated on 3-Feb-2021 Gene type: protein coding Also known as: LDLCQ3. See all available tests in GTR for this gene; Go to complete Gene record for HMGCR; Go to Variation Viewer for HMGCR variants; Summary HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial Hyperlipidemia and Sitosterolemia . Among its related pathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and Regulation of cholesterol biosynthesis by SREBP (SREBF) .

8 Mar 2017 This form of myositis, associated with antibodies to a protein called HMGCR, is a rare disease that requires long-term immunosuppression, but

Cat.No. 13533-1-AP.

1 May 2019 IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy

Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. 2020-11-11 · j, Strategy to generate Hmgcr KI/KI mice expressing HMGCR(K248R). k – p , Eight-week-old male mice were fed the HFHS diet for 7 weeks and then subjected to fasting-refeeding treatment. k Computers in biology and medicine, 42 (2), 156-163 (2011-12-20) The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary.

Anti-FHLl. Subgrupp av myosit. Antisyntetassyndrom. Ett observandum är dock att samma kliniska sjukdomsbild med positiva anti-HMGCR antikroppar och nekrotiserande myopati i muskelbiopsi kan förekomma utan HMG-CoA-reduktas ( 3-hydroxi-3-metyl-glutaryl-coenzym A-reduktas , officiellt förkortat HMGCR ) är det hastighetsreglerande enzymet av N Gårevik · 2013 · Citerat av 1 — The impact on the cholesterol homeostasis may be mediated by an increase of the HMGCR expression. There was a marked impact of the av A Miettinen — HMGCR-antikroppar. cN1A-antikroppar. Jo-1, PL-7, PL-12, OJ, EJ, HMGCR (3-hydroxy-3-metyl-glutaryl-CoA-re- duktas).
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Cited in 37 publications. Invitrogen Anti-HMGCR Polyclonal, Catalog # PA5-37367. Tested in Western Blot (WB), Immunocytochemistry (ICC) and Immunohistochemistry (Paraffin) (IHC 5 Mar 2021 HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Familial regulation of HMGCR has been investigated in detail. However, this enzyme acts very early in the cholesterol synthesis pathway, with 20 subsequent enzymes 22 Oct 2015 The patient's genetic background, characteristic histologic patterns (immune- mediated necrotizing myopathy), and presence of anti-HMGCR 25 Feb 2020 Abstract.

Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Anti-HMGCR antibody levels are reported to correlate with disease severity . However, they rarely, if ever, normalize even in patients that appear to have recovered fully .
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Gene: HMGCR ENSG00000113161 . twitter logo Twitter facebook logo Facebook email logo Email. Description. 3-hydroxy-3-methylglutaryl-CoA reductase

Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100ug/vial in Liquid form antibody. Antibody information for antibodies HPA008338 and CAB016797 used in analysis of ENSG00000113161 / HMGCR This is a phase 2, pilot, randomized, placebo-controlled trial of Gamunex-C IVIG as mono-therapy for HMGCoA reductase auto-antibody positive (HMGCR) necrotizing myopathy. The trial will test the feasibility and initial efficacy of Gamunex-C IVIG mono-therapy in HMGCR necrotizing myopathy. Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.

Gene name. HMGCR : Synonyms. Description. 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol) Entrez gene summary. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

HMGCR : Necrotizing autoimmune myopathy (NAM) is a serious but rare muscle disease strongly associated with autoantibodies to either signal recognition protein (SRP) or 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).(1) NAM typically manifests with subacute proximal limb muscle weakness and persistently elevated serum creatine kinase (CK) concentrations, but slower onsets can occur and complicate diagnosis.

HMGCR is differentially expressed in colorectal cancer and that positive expression is associated with favourable tumour characteristics and a prolonged survival in unadjusted analysis. HMGCR is upregulated in hepatocellular carcinoma associated with paraneoplastic hypercholesterolemia.